| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Biomaterial Applications
|
| Presentation Title |
Exploring the Potential of Strontium Substituted Amorphous Calcium Phosphate and Dicalcium Phosphate Dihydrate Based Hydroxyapatite Forming Bone Cement |
| Author(s) |
Prashant Nagesh Kumta, John Ohodnicki, Abhijit Roy |
| On-Site Speaker (Planned) |
John Ohodnicki |
| Abstract Scope |
Hydroxyapatite (HAp) bone cements are ubiquitous as biodegradable bone tissue engineering scaffolds. This is because of their 1. chemically similarity to the mineralized matrix of natural bone; 2. High stability in physiological environments; and 3. degradation without eliciting any toxicity. However, HAp cements typically display slow degradation rates and clinically undesirable long setting times. An amorphous calcium phosphate (ACP) and dicalcium phosphate dihydrate (DCPD) based cement is presented to address this issue including the influence of Strontium (Sr) on the HAp forming cement characteristics. XRD and SEM was utilized to characterize the synthesized precursor powders and the final cement phase composition. Compressive strength and percent porosity of the as-set and after aged cement was also assessed. Results conclude that increased amounts of Sr facilitate a more rapid HAp phase transformation coupled with increased MC3T3 in-vitro cell attachment and viability. Results of these studies will be presented and discussed. |