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Meeting MS&T22: Materials Science & Technology
Symposium Society for Biomaterials: Biomaterial Applications
Presentation Title Harnessing Perfluorocarbons to Enhance Oxygenation in Engineered Tissues
Author(s) Nic D. Leipzig
On-Site Speaker (Planned) Nic D. Leipzig
Abstract Scope Oxygen is fundamental to complex life as we know it, however, few biomaterial based strategies exist today to appropriately supply additional oxygen to sustain cellular processes for complex tissue functions. Our invention of crosslinked chitosan hydrogels with immobilized perfluorocarbons (PFCs) allows for the creation of biomimetic hydrogel platforms that harness PFC oxygenation abilities long-term. I will discuss the development of these materials and their subsequent applications. In vitro we have shown that our approach supports higher and tunable oxygen tensions, facilitates improved oxygen transport while enhancing cell survival/proliferation. We have gone on to apply these materials as wound dressings in animal models, and demonstrated improved healing responses due to enhanced oxygen bioavailability. Recently, we have formulated our materials into microfluidics generated microgels, which we have shown to significantly enhance 3D micro tissues, including liver spheroids that are larger, more viable, and more synthetically active compared to standard approaches.

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

Additive Manufacturing and Characterization of Stimuli-Responsive Biomaterials for Cardiovascular Stents
Altering the Size of Doxorubicin Loaded DOPE:DOPC Liposomes to Target Cancer-Associated Fibroblasts and Utilizing Size-dependent Selective Targeting
Antimicrobial Biomaterials Target Intracellular Infection
Bioactive Glass and Its Role in Healing
Bioactive Polyelectrolyte Layer by Layer Assembled Corrosion Resistant Coatings on Surface Treated MgAZ31 Alloys
Biodegradable Ceramic Coating on Lithium-Aluminum-Zinc (LAZ) and Lithium- Zinc (LZ) Magnesium Alloys Using Micro-arc Oxidation
Biodegradable Magnesium Fixation Wires for Bone Healing
Combinatorial Approaches to Blood Contacting Materials
Development of a Microfluidic Blood-Vessel-on-Chip Model
Development of Natural Polymer-based Hydrogels for Corneal Tissue Engineering Applications
Development of Tissue-Specific, Perfusable Vasculature in Microphysiological Systems
Electrospraying Chitosan on Co-electrospun PCL/PVA Composite with Mesoporous Silica Particles to Release Curcumin for Skin Tissue Engineering Application
Exploring Single Electrospun PLGA Fiber Mechanics and Fiber Mat Applications in Cardiac Bioengineering
Exploring the Potential of Strontium Substituted Amorphous Calcium Phosphate and Dicalcium Phosphate Dihydrate Based Hydroxyapatite Forming Bone Cement
Harnessing Biological Functions in Dental Materials
Harnessing Perfluorocarbons to Enhance Oxygenation in Engineered Tissues
Hybrid 3D Bioprinting of Tissue Engineering Scaffolds with Dual Delivery Capability for Anticancer Drugs
Hydroxyapatite Loaded with 2-heptylcyclopropane-1-carboxylic Acid Inhibits S. Aureus Biofilm Formation
In Vitro Biochemical Analysis of Bioactive Glass Ionomer Cement (45S5) with Citric Acid as Setting Modifier
Magnesium-Based Nanocomposites for Bone Fracture Repair
Novel Biodegradable Porous Magnesium Alloy Scaffolds for Critical Sized Calvarial Bone Defect Reconstruction
Plant Polymer for Climate and Health Management
Platinum Wire-based Aptasensors Exploiting Self-assembled Monolayer (SAM) Components for Cardiac Biomarker Detection
Silanized Titanium for Delivery of Hydrophobic Therapeutic in Aqueous Environment
Silver Doped Titanium Oxide Layers for Improved Photocatalytic Activity and Potential Antibacterial Properties of Titanium Implants
Three-dimensional (3D) Iron Oxide Nanoparticles via Green Synthesis: A Review on Their Synthesis and Antibacterial Application
Utilizing Thiolyne Click Chemistry to Target Cancer Cells Using Folate Conjugated Liposomes

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