Zn and Zn-based alloys as biodegradable material have drawn more and more attention in recent years due to their good mechanical properties, lower degradation rate than Mg and acceptable biocompatibility. However, too low degradation rate and serous self-aging phenomena are two main challenges for future clinical applications. Advanced alloying technique is the key to the solutions. In order to enhance the corrosion rate, the alloying elements with low cytotoxity tend to form the dispersed cathodic phase to the Zn matrix, causing accelerated corrosion via the micro-galvanic effect, should be selected. On the other hand, in order to suppress the self-aging phenomena of Zn-based alloys, the thermal stability of Zn-based alloy matrix should be improved significantly. In this talk, the design strategy of biodegradable Zn-based alloy will be proposed and the novel Zn-Cu-based alloys with high comprehensive properties for cardiovascular stents will be introduced systematically.