|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Biological Materials Science
||Localized Nanomechancial Characterization of Arterial Stiffening in Human Arteries with the PeakForce Quantitative Nanomechanical Mapping Technique
||Zhuo Chang, Riaz Akhtar, Maria Lyck Hansen, Lars Melholt Rasmussen, Po-Yu Chen, Paolo Paoletti
|On-Site Speaker (Planned)
Arterial stiffening occurs with age and is highly related to cardiovascular diseases. However, nano-scale alterations due to arterial stiffening are not well understood. Here, we utilized the atomic forice microscopy (AFM) PeakForce Quantitative Nanomechanical Mapping (PF-QNM) mode. PF-QNM allows visualization of both surface topography and mechanical properties. We characterized nanomechanical properties of different layers in internal mammary arteries (IMA) from patents with high and low pulse wave velocity (PWV), an in vivo measure of arterial stiffness, in air and liquid. Overall, the dry samples were stiffer overall in the high PWV group (Low; 2038.7 ± 60 MPa, High; 2301.6 ± 48 MPa) (p < 0.0001), and in each layer. In hydrated samples, the medial layer was significantly stiffer in the high PWV group (Low; 228.4 ± 15.6 kPa, High; 735.8 ± 108.8 kPa) (p < 0.0001). Our nanomechanical results associate with PWV data and provide new insight into arterial stiffening.
||Planned: Supplemental Proceedings volume