|About this Abstract
||2018 TMS Annual Meeting & Exhibition
||Biological Materials Science
||Nanocomposite Heating Probes for Thermoablation of Cancerous Cells
||Kwabena Kan-Dapaah, Nima Rahbar, Wole Soboyejo
|On-Site Speaker (Planned)
Probe-based techniques for the destruction of cancer cells have received a lot of attention because it provides a minimally invasive strategy that localizes treatment. Although radiofrequency ablation is the most widely used method, skin burns at the site of the grounding pads are a major complication that limits lesion sizes. This work presents a novel polymeric nanocomposite-based probe that has the potential to achieve reasonable lesion sizes without skin burns. First, the concept and its embodiment are elucidated. Then, to assess the feasibility of the probe, the structural and magnetic properties of a model nanocomposite system, magnetic nanoparticle filled polydimethylsiloxane (PDMS), is studied and used in a 3D multiphysics finite element method model to predict the in-vivo performance. The results show that the probe is about is able to generate enough heat to achieve reasonable lesion sizes. The implications of the results are discussed for potential application in cancer treatment.
||Planned: Supplemental Proceedings volume