|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Pan American Materials Congress: Advanced Biomaterials
||Synthesis of Fish Scale Extracted Hydroxyapatite and Chitosan Composite Scaffolds by Freeze Casting for Biomedical and Environmental Applications
||Wen-Kuang Liu, Bor-Shuang Liaw, Haw-Kai Chang, Po-Yu Chen
|On-Site Speaker (Planned)
Fish scales are typically considered as wastes in fishery industries yet important collagen and hydroxyapatite sources. In this study, hydroxyapatite minerals were extracted from scales of Tilapia fish (Oreochromis mossambicus) and utilized as raw materials for scaffolds synthesized by freeze casting technique. Chitosan was further coated on the hydroxyapatite scaffolds, forming bio-mineral/polymer composites. Microstructural features of scaffolds were characterized by SEM and micro-CT, revealing uniform laminar structures with 10-80 μm channels depending on cooling rates. The scaffolds were suitable for cell migration and growth, meanwhile exhibited good mechanical strength. In vitro test was done by culturing human osteoblast cells on the scaffolds, and cell viability was evaluated by MTS assay. The other application was the capability to remove heavy metal ions from waste water, which was quantified by Atomic Absorption Spectrometer. The fish scale derived hydroxyapatite/chitosan scaffolds have great potential to be applied in various fields.
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