In binder jet 3D printing (BJ3DP), strongly coupled fluid-particle interaction is a primary factor governing the overall quality of the final part. Wide scale adoption of this method for demanding, mission-critical applications, such as high-performance aerospace components, requires improved mechanical properties and operating characteristics of the end use parts. This increased fidelity may be achieved with better understanding of the interfacial physics and complex fluid-particle flow that is fundamental to the BJ3DP process. In this work, we seek to elucidate the fluid and particle dynamics occurring upon impact of a liquid droplet onto a powder bed – effects of particle and fluid properties as well as process parameters (droplet size, impact velocity, jetting frequency, etc.) are studied. The investigation is carried out through numerical simulation with a multiphase computational fluid dynamics (CFD) framework. Furthermore, we employ high-speed, microscopic imaging of the droplet impact event for experimental validation.