Barley, flax, and hemp are among the most important agricultural products in Alberta. Grown for their seeds and grains, the post-harvest biomass, straw and shives, is typically left in the soil as considered of low value by-products. Here we demonstrate a novel chemical conversion protocol to transform Alberta-sourced biomass into lignocellulosic bioplastics with antimicrobial activity and tunable mechanical properties for medical packaging application. The antimicrobial activity is achieved by incorporating antimicrobial peptides into the bioplastics, other than the current market-dominated silver-based antimicrobials. In contrast to the human health and environmental risky silver, antimicrobial peptides fight preferentially against the prokaryotes (the bacterial cells) not the eukaryotes (the mammalian cells), which enables them to provide safe and natural protection to patients and to be environmentally green. At its core, this project addresses the loss of antimicrobial activity as a result of peptide and bioplastics incorporation, a key challenge faced by antimicrobial technology.