About this Abstract |
Meeting |
MS&T22: Materials Science & Technology
|
Symposium
|
14th Symposium on Green and Sustainable Technologies for Materials Manufacturing and Processing
|
Presentation Title |
A Computationally Engineered Sustainable Approach for Tuning Nanoclays for Biomaterials Applications |
Author(s) |
Kalpana S. Katti, Krishna Kundu, Hanmant Gaikwad, Dinesh R Katti |
On-Site Speaker (Planned) |
Kalpana S. Katti |
Abstract Scope |
Clay-based materials have been extensively used in medicine for wound dressings, drug delivery and regenerative medicine. Our group developed the ‘Altered-Phase-Theory’ for polymer-clay-nanocomposites (PCNs) that elucidates methodology for a simulation-based design of PCNs. We report here the use of different amino acids as modifiers for design of PCNs for scaffolds for bone tissue engineering. The amino acids enable a biomimetic mineralization of hydroxyapatite inside the nanoclay galleries. In addition, molecular dynamics simulations indicate extensive interaction energies in the novel PCNs. The variation of amino acids enables tuning of both the mechanical properties of the scaffolds for bone tissue engineering as well as biological activity for the design of environmentally benign and sustainable nanocomposites. Unlike several other nanomaterials that exhibit toxicity, the engineered nanoclays elicit favorable response such as enabling stem cell differentiation. Thus, biomolecule modified nanoclays represent a next generation tunable nanocomposite for biomedical applications with far reduced environmental footprint. |