The effect of lattice distortion on mechanical properties and deformation mechanism was investigated at −145 °C and room temperature. In the present study, tensile tests of pure Ni, Ni-2at.% W (medium lattice distortion), Ni-4at.% W (severe lattice distortion which is compatible with CrFeNi and CoCrFeMnNi), equi-atomic CrFeNi and equi-atomic CoCrFeMnNi high entropy alloy were conducted. Strain hardening behavior was investigated by strain hardening rate, hardening exponent evolution and Crussard-Jaoul analysis. The tensile tests showed that all of these had better mechanical properties at lower temperature. CoCrFeMnNi is due to the deformation twin, therefore, Ni, Ni-2at.% W and Ni-4at.% W are because the less dynamic recovery, which cause the increase of work hardening rate according to Considère criterion. As for the deformation mechanism, in addition to lattice distortion, factors such as stacking fault energy, critical twinning stress and lattice distortion distributions were used to explain the differences of strain hardening behavior.