|About this Abstract
||Materials Science & Technology 2011
||Next Generation Biomaterials
||An Experiment-Simulation Approach to Determine Electrospun Fiber Properties
||Greg Ebersole, Jackie Ohmura, Heather M Powell, Peter M Anderson
|On-Site Speaker (Planned)
||Peter M Anderson
Constitutive properties of electrospun fibers may be determined from elaborate single-fiber testing modes. This work proposes a complementary experiment-simulation approach. Specifically, finite element simulations are developed that capture discrete fiber straightening, reorientation, and contact during scaffold deformation. Model inputs are initial fiber geometries and fiber mechanical properties. The former is provided by confocal images of scaffolds prior to deformation. The latter is unknown but is determined by tuning the simulations to reproduce two key experimental features: (1) statistical descriptions of changing fiber shape and orientation with deformation and (2) uniaxial scaffold stress-strain response. The results reveal the intrinsic, nonlinear response of hydrated, electrospun, collagen fibers embedded in a scaffold. In the process, we introduce a statistical description of fiber shapes based on Fourier coefficients and discuss extensions of the method to study time-dependent, viscoelastic response.