We are at the dawn of a new engineering era with additive manufacturing leaving its infancy combined with effective design strategies, process modeling, topology optimization and materials modeling. We are seeing substantial changes in manufacturing processes for which complexity is not a limiting factor. In aerospace applications these changes are leading to revolutionary shifts including substantial mass reduction, parts-count reduction, gradient materials and the possibility in-situ resource utilization and in-space manufacturing. Other similarly valuable design trends include topology optimization, generative, subtractive and multifunctional, non-linear designs resembling biomemetics have also emerged. Full scale modeling of manufactured objects is near with detailed parts of the problem being developed including: atomistic , kinetic, thermodynamic, process, microstructure, and stress models. For the first time we can bring together capabilities of design, topology, materials and process modeling allowing engineering from the atoms to complete large-scale systems.