|About this Abstract
||2018 TMS Annual Meeting & Exhibition
||Biodegradable Materials for Medical Applications
||Development of a New Biodegradable Surgical Clip Made of a Magnesium Alloy: Evaluation of its Safety and Tolerability for Canine Cholecystectomy
||Takumi Fukumoto, Toshihiko Yoshida, Takeshi Urade, Naoko Ikeo, Toshiji Mukai
|On-Site Speaker (Planned)
Background: We developed a biodegradable magnesium-zinc-calcium alloy clip with good biological compatibility and enough clamping capability as a surgical clip. In this study, we verified the safety and tolerability of this clip. Methods: Nine beagles were used. We performed cholecystectomy and ligated the cystic duct by magnesium alloy or titanium clips. The chronological change of clips and artifact formation were compared at 1, 4, 12, 18, and 24 weeks postsurgery by CT. The animals were euthanized at the end of the observation period, and the clips were removed to evaluate their biodegradability. We also evaluated their effect on the living body by blood biochemistry. Results: The magnesium alloy clip formed much fewer artifacts than the titanium clip, and it was almost absorbed at 6 months postsurgery. There were no postoperative complications and no elevation of constituent elements such as magnesium, calcium, and zinc during the observation period in both groups.
||Planned: Supplemental Proceedings volume