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Meeting 2017 TMS Annual Meeting & Exhibition
Symposium Bio-Nano Interfaces and Engineering Applications
Presentation Title Modulation of Antimicrobial Peptide Activity at the Medical Implant Interface through Chimeric Peptide Spacer Design
Author(s) Cate Wisdom, Sarah Kay VanOosten, Kyle Boone, Paul Arnold, Malcolm L. Snead, Candan Tamerler
On-Site Speaker (Planned) Cate Wisdom
Abstract Scope Surgical site infection is a common cause of post-operative morbidity, often leading to implant failure, ultimately requiring revision surgery. Controlling the bio-material interface plays a critical role in reducing infection. We engineered a biomimetic interface, utilizing a novel single molecule to self anchor and bring antimicrobial property to the bio-material interface. Titanium surfaces coated with the engineered peptide showed bacteria reduction up to approximately 10-fold for <I>S. mutans</I> and 50-fold for <I>S. epidermidis</I>. Our design includes offering a spacer design, which is incorporated in between the bioactive domains to improve the functional components. As a result, fibroblast attachment and metabolism at the interface were improved compared to the untreated surface. Biomimetic interfaces formed with this chimeric peptide offer interminable potential by coupling antimicrobial and improved host cell responses to implantable titanium materials, and the peptide based approach is extendable to other applications. Supported by AR06224/NIH-NIAMS, DE025476/NIH-NIDCR.
Proceedings Inclusion? Planned: Supplemental Proceedings volume

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

A Bone-mimetic 3D Metastasis Cancer Tumor Model
Atomistic Simulations of the Interaction of Gold Surfaces and Nanoparticles with Amyloidogenic Proteins and Peptides
Bio-inspired Syntheses of Self-cleaning Coatings and Oil-water Separation Interfaces by Atmospheric Pressure Plasma and Freeze Casting Techniques
Bio-Nano-Technology toward Smart Interfaces and Functional Hybrid Materials
Characteristics of von Willebrand Factor Adhesion on Collagen Surface under Flow
Characterization of Solid-supported Thin Films and Molecular Interactions Using Multi-parametric Surface Plasmon Resonance
Computational Design of Biological-Inorganic Materials from the Nanoscale
Computational Models of Peptide-Surface Interactions Drawn from Bacterial Display Studies
Designing Peptides with Antimicrobial Properties using Rules of Induction
Early Study on Surface Nano-engineering of Endovascular Zinc Implants and Resulting Effects on Biodegradation and Biocompatiblity
Engineered Bio-Nano Interfaces of Titanium Biomedical Implants
Engineering Hydrogels with Bioactive Nanomaterials for Bone Regeneration Applications
Engineering Lactate Oxidases with Metal Binding Peptides towards Lactate Monitoring
Engineering Solid Binding Proteins to Control Functional Nanostructure Assembly, Solid Interactions and Inorganic Mineralization
Formation of Planer Lipid Bilayers on 2D Materials Assisted by Self-assembled Peptides
H-6: Development of Functional Peptides with β-sheet Structures for the Self-assembly on Two-dimensional Materials
H-7: Regeneration Sands Foundry for Deterioration Bacterial in Industrial Scale
Interfaces Drive the Mechanics of Hard Biological Materials: Discrete Element Models and Bioinspired Prototypes
Interfacing Biomolecules with Nanomaterials: Structure and Function at the Atomic-scale
Interfacing Freeze-Cast Biopolymer Scaffolds with Tissue In Vivo: Effects of Composition and Structure on Integration and Degradation
Materials Construction through Peptide Design and Solution Assembly
Modeling of Nanocomposite Scaffolds and Interfacial Behavior during Tissue Regeneration and Scaffold Degradation: A Multiscale Mechanics Approach
Modulation of Antimicrobial Peptide Activity at the Medical Implant Interface through Chimeric Peptide Spacer Design
Multidimensional Atomic Force Microscopy for Physical and Biological Interfaces: Seeing the Invisible and Feeling the Insensible?
Nanometrically Smooth Ultrafine Grained Titanium Alloy Surfaces
Nanostructured Surfaces for Dental Implant Applications
Novel Gyratory Processes to Manufacture Bionanointerfaces
Peptide Enabled Addressable Immobilization of Kinetically Matched Fusion Enzymes in Membrane Flow Bioreactors
Principles of Molecular Biomimetics versus Materials Science and Engineering
Silica Nanostructured Platform for Affinity Capture of Tumor-Derived Exosomes
Solution Plasma Materials Processing from Natural Products
The Role of Silica in Composite Materials for Bioengineering Applications Including Bone Regeneration and Cell Based Therapies- The Importance of the Interface
Toughness-Enhancing Linear Metastructure in the Recluse Spider’s Nanoribbon Silk

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