|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Bio-Nano Interfaces and Engineering Applications
||Modulation of Antimicrobial Peptide Activity at the Medical Implant Interface through Chimeric Peptide Spacer Design
||Cate Wisdom, Sarah Kay VanOosten, Kyle Boone, Paul Arnold, Malcolm L. Snead, Candan Tamerler
|On-Site Speaker (Planned)
Surgical site infection is a common cause of post-operative morbidity, often leading to implant failure, ultimately requiring revision surgery. Controlling the bio-material interface plays a critical role in reducing infection. We engineered a biomimetic interface, utilizing a novel single molecule to self anchor and bring antimicrobial property to the bio-material interface. Titanium surfaces coated with the engineered peptide showed bacteria reduction up to approximately 10-fold for S. mutans and 50-fold for S. epidermidis. Our design includes offering a spacer design, which is incorporated in between the bioactive domains to improve the functional components. As a result, fibroblast attachment and metabolism at the interface were improved compared to the untreated surface. Biomimetic interfaces formed with this chimeric peptide offer interminable potential by coupling antimicrobial and improved host cell responses to implantable titanium materials, and the peptide based approach is extendable to other applications. Supported by AR06224/NIH-NIAMS, DE025476/NIH-NIDCR.
||Planned: Supplemental Proceedings volume