Abstract Scope |
Creating scaffolds for skin injury remains challenging to heal different wounds and antibacterial properties to prevent infection. In this paper, we presented a composite co-electrospun polycaprolactone (PCL)/ Polyvinyl alcohol (PVA) scaffolds with mesoporous silica particles (MSP), which were electrosprayed by chitosan for potential skin tissue engineering. For this purpose, co-electrospinning of enhanced PCLwith MSP and PVA, which loaded curcumin, in the following, fabricated scaffolds were electrosprayed with chitosan and then characterized by different techniques/assays in vitro. Scanning electron microscopy and infrared spectroscopy were used to study morphology and chemical structure of electrospun scaffolds. The scaffolds were tested by measuring the contact angle to verify the hydrophilicity. In addition, the drug delivery, antibacterial activity, and cytotoxicity were analyzed in vitro. The results showed that this structure is effective for drug delivery, with high antimicrobial properties and low toxicity against fibroblast cells. Adding PVA and chitosan increased the hydrophilicity of skin scaffolds. |