|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Pan American Materials Congress: Advanced Biomaterials
||Comparative Spectroscopic Studies on the Interaction of Nickel Selenide Quantum Dots with Serum Albumins
||Selvaraj Naveenraj, Ramalinga Viswanathan Mangalaraja, Thangaraj Pandiyarajan, Sambandam Anandan
|On-Site Speaker (Planned)
Nickel selenide (NiSe) quantum dots (QDs) of size less than 5 nm were successfully synthesized by a simple microwave process in the ethylene glycol medium using inexpensive precursors such as nickel chloride, sodium selenite, hydrazine (reducing agent) and starch (capping agent). Thus synthesized NiSe QDs were characterized using UV–vis spectroscopy, X-ray diffraction (XRD), high resolution transmission electron microscopy (HRTEM), and energy-dispersive X-ray spectroscopy (EDS). Their <I>in-vitro</I> interactions with human serum albumin (HSA) and bovine serum albumin (BSA) were investigated using UV-vis, and fluorescence spectroscopic techniques. The spectral results confirmed that NiSe QDs quenched the fluorescence of serum albumins through static quenching mechanism and the fluorophore site is near the tryptophan moiety of serum albumins. The binding constant K<SUB>b</SUB> obtained in the fluorescence studies indicated that NiSe QDs have more affinity towards HSA than that of BSA. These results will shed light towards the understanding of the NiSe QDs pharmacokinetics.
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