|About this Abstract
||Materials Science & Technology 2016
||Next Generation Biomaterials
||In Vivo Evaluation of Novel Amorphous Silicon Oxynitrophosphide Implant Coatings for Rapid Bone Healing
||Venu G Varanasi, Azhar Ilyas, Pranesh Aswath, Harry Kim, Phillip Kramer
|On-Site Speaker (Planned)
||Venu G Varanasi
Structurally unstable fracture sites require permanent or semi-permanent bone implants that are typically made of titanium (Ti) or other inert metals. The material properties of these fixative devices play significant role in bone healing. A material that that reacts favorably and adheres well to the in-vivo bone environment is critical for rapid bone healing. Here, we propose the use of nanofabricated amorphous silicon oxynitrophosphide (Si-O-N-P) as an overlay onto metal implants in load-bearing bone defect applications. We will exhibit the mechanical and chemical characterization of nanofabricated device to assess its adhesion to the underlying metal/metal oxide. We will also reveal its osteoinductive behavior when placed in biological environment in-vitro and craniofacial defects in-vivo. The interaction of the elemental components at bone-SiONP/TiO2/Ti interface will be presented and discussed. A novel antioxidant role will be revealed that will illustrate the connection between immunological and pathways that enhance bone healing.