|About this Abstract
||2018 TMS Annual Meeting & Exhibition
||Biodegradable Materials for Medical Applications
||Development of Porous and Biodegradable Hydroxyapatite/Mg Alloy Composite as Biodegradable Implants for Orthopaedic Applications
||Jae-Young Jung, Yajur N. Maker, Sung Sik Hur, Steven E. Naleway, Gracia Innocentia, Kathy Kang , Marc A. Meyers, Shu Chien, Joanna McKittrick
|On-Site Speaker (Planned)
To better serve patient healing and comfort needs, biodegradable bone implant materials have been actively developed for various orthopedic applications. We have attempted to improve current magnesium(Mg)-based biodegradable metal implants by employing a novel method: 1) the use of a specially manufactured Mg-Ca-Zn alloy, which was hollowed as a matrix material to provide macroporosity, and 2) freeze-casted into using a hydroxyapatite (HA) slurry, offering the second level of microporosity and biocompatibility. Unlike conventional freeze casting methods which result in in-plane parallel lamellar alignment of pores, radial alignment of the HA pores resulted at the center of Mg matrix, which mimics the natural alignment of the lamella with respect to the lacunae spaces. In addition, the porous structure provided a larger surface area to the cells with an aligned orientation. The measured degradation rate was remained as same as the sole Mg alloy without rapid corrosion induced by the process.
||Planned: Supplemental Proceedings volume