|About this Abstract
||Materials Science & Technology 2011
||Next Generation Biomaterials
||Corrosion Resistance and Cytotoxicity of Degradable Metallic Implants for Orthopedic Applications
||Puneet Gill, Norman Munroe, Amit Datye, Rupak Dua, Sharan Ramaswamy
|On-Site Speaker (Planned)
Orthopedic implants are prone to corrosion damage as a result of repeated relative surface motion, high induced load and local environment. Failure of these devices can result from many sources such as, alloy properties, manufacturing methods, microstructure, etc. This study focuses on the development of new magnesium based biodegradable alloys with good biocompatibility, osteoinductive and non-toxic properties. The corrosion resistance of mechanical polished and surface treated alloys was assessed at 37 oC in PBS containing amino acids. Sulforhodamine-B (SRB) assay was used to evaluate the cytoxicity of ions released during corrosion on Human osteoblast cells (HOC). HOC were grown on the material’s surface to access their cell growth. The role of surface energy, alloy composition and morphology on cell proliferation were investigated.