| About this Abstract |
| Meeting |
2011 TMS Annual Meeting & Exhibition
|
| Symposium
|
Surfaces and Heterostructures at Nano- or Micro-Scale and Their Characterization, Properties, and Applications
|
| Presentation Title |
Surface Modification of Microneedles for Antimicrobial Activity |
| Author(s) |
R. J. Narayan, Shaun Gittard, Boris Chichkov, Aleksandr Ovsianikov, Shane Stafslien, Bret Chisholm |
| On-Site Speaker (Planned) |
R. J. Narayan |
| Abstract Scope |
Microneedles with antimicrobial properties may be prepared by coating microneedles with materials that exhibit antimicrobial activity. Silver exhibits broad-spectrum activity against bacteria; this activity is attributed to disruption of electron transport, as well as interruption of deoxyribonucleic acid replication. In this study, silver thin films were deposited on the surfaces of polymer microneedles at room temperature using pulsed laser deposition. We fabricated silver-coated microneedles using a two-step process, which involved two photon polymerization-micromolding and pulsed laser deposition. In the first step, solid microneedle arrays were prepared using organically-modified ceramic material by means of two photon polymerization-micromolding. In the second step, pulsed laser deposition was used to deposit silver thin films on these microneedle arrays. An absence of S. aureus growth was noted beneath the silver-coated microneedle array. In addition, inhibited growth was observed in the region surrounding the microneedle array, which suggested that silver was released into the agar. |
| Proceedings Inclusion? |
Planned: A CD-only volume |