Metallic biomaterials with excellent combination of mechanical properties, biocompatibility, corrosion resistance, have been used extensively in clinic. However, biologically inert is one of the problem that limiting the development of metallic biomaterials. Copper is well known for strong antimicrobial ability, and Cu is a necessary trace element in the human body. Meanwhile, Cu has not only been proved to have many useful bio-functions in human bodies, but also a famous alloying element in metallurgy. Herein, a little bit oversaturated amount of Cu was immobilized into the medical metallic materials, such as titanium, stainless steel, and cobalt alloy during smelting process to get Cu-bearing materials. This creative idea has been verified that Cu-bearing materials have bioactive properties including anti-microbial activity, osteogenesis and angiogenesis with excellent biocompatibility because of the trace release amount of Cu, which is potential to be used as implant devices in orthopedic, coronary system, and oral environment.