| About this Abstract |
| Meeting |
MS&T21: Materials Science & Technology
|
| Symposium
|
Surface Engineering and Characterization of Titanium and Titanium Alloys
|
| Presentation Title |
Enhancing Differentiation of Preosteoblast on Selective Laser Melting Titanium Implants Treated with Mixed Acid and Heat |
| Author(s) |
Phuc Thi Minh Le, Seine A. Shintani, Hiroaki Takadama, Morihiro Ito, Tatsuya Kakutani, Hisashi Kitagaki, Shuntaro Terauchi, Takaaki Ueno, Hiroyuki Nakano, Yoichiro Nakajima, Kazuya Inoue, Tomiharu Matsushita, Seiji Yamaguchi |
| On-Site Speaker (Planned) |
Phuc Thi Minh Le |
| Abstract Scope |
Selective laser melting (SLM) is a promising technique that realizes personalized characteristics to rightly fit the implants to bone defects. These surfaces could be modified to promote bone-bonding by a certain chemical and heat treatment. In this study, we evaluated preosteoblast differentiation cultured on titanium (Ti) prepared by SLM subjected to mixed acid and heat (SLM-Ti MAH). Commercial available Ti with a smooth surface was used as a control. The acid and heat treatment increased surface roughness, wettability, and apatite formation which are useful for cell attachment. Quantitative measurement of osteogenic-related gene expression indicated preosteoblast on the SLM-Ti MAH presented a stronger osteogenic differentiation tendency at the genetic level. Alp activity and extracellular matrix mineralization on the treated SLM-Ti are higher than control. This study demonstrated that treated SLM-Ti enhanced preosteoblast differentiation. The developed SLM-Ti surface shows great potential for the next generation of orthopedic and dental implants.L |