ProgramMaster Logo
Conference Tools for 2018 TMS Annual Meeting & Exhibition
Login
Register as a New User
Help
Submit An Abstract
Propose A Symposium
Presenter/Author Tools
Organizer/Editor Tools
About this Abstract
Meeting 2018 TMS Annual Meeting & Exhibition
Symposium Bio-nano Interfaces and Engineering Applications Symposium
Presentation Title Bioconjugated Nanoparticle Imaging Probes for Molecular Imaging with Computed Tomography
Author(s) Ryan K. Roeder, Tyler E. Curtis, Prakash D. Nallathamby, Tyler A. Finamore, Lisa E. Irimata, Tracie L. McGinnity, Lisa E. Cole, Tracy Vargo-Gogola, Karen D. Cowden Dahl
On-Site Speaker (Planned) Ryan K. Roeder
Abstract Scope X-ray computed tomography (CT) provides non-invasive, three-dimensional, anatomic imaging at high spatial resolution and relatively low cost for clinical diagnostic imaging, but is limited by relatively low sensitivity and soft tissue contrast. Therefore, bioconjugated nanoparticle imaging probes have been developed to address these limitations and enable quantitative molecular imaging with CT. Core-shell nanoparticles provide a powerful platform for designing tailored imaging probes. The composition of the core is chosen for enabling strong X-ray contrast, multi-agent imaging with a spectral library of compositions, and multimodal imaging. A silica shell enables protective, biocompatible encapsulation of the core composition, volume-loading fluorophores for multimodal imaging, and facile surface functionalization with biomolecules for targeted delivery. Examples will be presented to demonstrate quantitative molecular imaging of multi-probe/tissue compositions, scaffold degradation in tissue engineering, cell populations overexpressing biomarkers, tumors and associated abnormalities (e.g., microcalcifications) using both conventional contrast-enhanced CT and novel photon-counting spectral CT systems.
Proceedings Inclusion? Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

Bioconjugated Nanoparticle Imaging Probes for Molecular Imaging with Computed Tomography
Biofilm Formation Behavior on Polymer Brush Surfaces by E.coli and S. Epidermidis
Biomolecular Design of Soft Interfaces for Technology and Medicine
Chemically Functionalised Graphene FET with Double Conductance Minima for the Label-free Sensing of Exosomes
Computational Study of Selective Adsorption of Peptides on MoS2 Surface
Connecting Biology and Electronics with Protons: From Ion Channels to Cells
Development of FRET Biosensor Based on Aptamer/Functionalized Graphene for Ultrasensitive Detection of Bisphenol A and Discrimination from Analogues
Discovery of Biomaterials by Simulation and Experiment: Catalysts, Composites, and Therapeutics
Effects of Hydration and Mineralization on the Mechanical Behavior of Collagen Fibrils
Investigating the Interaction of Amyloidogenic Proteins with Inorganic Surfaces, Nanoparticles and Biomolecules by Atomistic Simulations
Modeling the Mechanics of Cancer Cells on Tissue Engineering Substrates
Nanoclay Based Tissue Engineering Scaffolds for Mimicking Biointerfaces in Mesenchymal to Epithelial Transision of Prostate and Breast Cancer Metastasis to Bone
Nanoparticles-grafted Functionalized Graphene Coated with Nanostructured Polyaniline Layered Nanocomposites for High-performance Biosensors
Nanoscale Structure and Properties of Biomaterials
New Antimicrobial Peptides Generated through Genetic Algorithm Approach Using Chemical Property Based Cross-over 
Oligopeptides and Recombinamers at Surfaces and Interfaces to Address Oral Infections
Revealing the Full Hierarchical Structure of Spider Silks across All Length Scales
Revealing the Multi-functional Surface and Material Property of Venus Flytrap (Dionaea Muscipula)
Self-assembled Formate Dehydrogenase-metal Nanoparticle Hybrids Improved Enzyme Stability
Single Molecular Imaging of Fluorescent-tagged Peptides Diffusing on a Surface of Boron Nitride
Smart Biomaterials for MoS2 and Gold Mining
Surface Modification of Ti6Al4V to Confer Antibacterial Properties against Listeria Monocytogenes
Synthesis and Characterization of Superomniphobic Surfaces Inspired by Springtails
Transmission Synchrotron X-ray Tomography and Nano-indentation Measurements for the Investigation of the Teeth Microstructure of Dinosaurs
Transparent Titanium Dioxide Nanotubes: Processing, Characterization, and Application in Establishing Cellular Response Mechanisms
Use of Nanostructured Diamond in Medical Device Applications

Questions about ProgramMaster? Contact programming@programmaster.org