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Meeting 2018 TMS Annual Meeting & Exhibition
Symposium Bio-nano Interfaces and Engineering Applications Symposium
Presentation Title Bioconjugated Nanoparticle Imaging Probes for Molecular Imaging with Computed Tomography
Author(s) Ryan K. Roeder, Tyler E. Curtis, Prakash D. Nallathamby, Tyler A. Finamore, Lisa E. Irimata, Tracie L. McGinnity, Lisa E. Cole, Tracy Vargo-Gogola, Karen D. Cowden Dahl
On-Site Speaker (Planned) Ryan K. Roeder
Abstract Scope X-ray computed tomography (CT) provides non-invasive, three-dimensional, anatomic imaging at high spatial resolution and relatively low cost for clinical diagnostic imaging, but is limited by relatively low sensitivity and soft tissue contrast. Therefore, bioconjugated nanoparticle imaging probes have been developed to address these limitations and enable quantitative molecular imaging with CT. Core-shell nanoparticles provide a powerful platform for designing tailored imaging probes. The composition of the core is chosen for enabling strong X-ray contrast, multi-agent imaging with a spectral library of compositions, and multimodal imaging. A silica shell enables protective, biocompatible encapsulation of the core composition, volume-loading fluorophores for multimodal imaging, and facile surface functionalization with biomolecules for targeted delivery. Examples will be presented to demonstrate quantitative molecular imaging of multi-probe/tissue compositions, scaffold degradation in tissue engineering, cell populations overexpressing biomarkers, tumors and associated abnormalities (e.g., microcalcifications) using both conventional contrast-enhanced CT and novel photon-counting spectral CT systems.
Proceedings Inclusion? Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)


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