This talk will present an efficient homogenization-based topology optimization method for optimizing the design of functionally-graded lattice infills in components processed by laser powder bed fusion. In the proposed method, homogenization is first performed to model the effective properties of lattice structures as a function of relative density. Then the homogenized model is employed directly in conventional density-based topology optimization algorithm to compute the optimal density distribution for the design component under consideration. The final step in this method is to reconstruct the CAD model for the optimized component with graded lattice infill from the optimized density distribution. The proposed optimization method has been validated by comparing results obtained by the homogenized model, direct numerical simulation, and experimental testing for different design scenarios involving stress constraints, natural frequency, convective cooling, and support structure design, which are of great interest to the Navy.