|About this Abstract
||Materials Science & Technology 2012
||Surface Properties of Biomaterials III
||Controlled Release and Release Behavior of Lovastatin From PCL Coating on β-TCP
||Solaiman Tarafder, Kelly Nansen, Susmita Bose
|On-Site Speaker (Planned)
The approach of local drug delivery from polymeric coating is currently getting significant attention for controlled and sustained release for both soft and hard tissue engineering applications. Lovastatin is a cholesterol lowering drug. 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibition by lovastatin promotes osteoblast activity and suppresses osteoclast activity. Objective of this research was to minimize burst release through understanding the release kinetics of lovastatin from polycaprolactone (PCL) coating on β-tricalcium phosphate (β-TCP). Lovastatin was incorporated into biodegradable water insoluble PCL coating on β-TCP. A controlled lovastatin release was observed from PCL coating compared to absence of PCL coating on β-TCP. The hydrophilic-hydrophobic and hydrophobic-hydrophobic interactions between lovastatin-PCL were found to be the key factors controlling the release kinetics of lovastatin from PCL coating in addition to diffusion and matrix solubility. Understanding the lovastatin release chemistry from PCL will be beneficial for designing drug delivery devices from polymeric coating or scaffolds.
||Planned: None Selected