|About this Abstract
||Materials Science & Technology 2011
||Next Generation Biomaterials
||Electrically Triggered Drug Delivery Using Nanoporous Electrodes
||David B. Robinson, Shaun D. Gittard, Chung-An Max Wu, Roger J. Narayan
|On-Site Speaker (Planned)
||David B. Robinson
Nanoporous electrodes, such as those made from carbon or gold, can capture and release ionic analytes at concentrations near 1 mole per liter of pore volume through capacitive charging or electrochemically reversible adsorption. In vitro studies suggest that this phenomenon can be the basis for a noninvasive, precise, and programmable drug delivery method. It eliminates the need for bulk fluid delivery to target tissue and requires only a thin electrical connection, minimizing pain and tissue disruption. Timing of release can be flexibly controlled. Compared to iontophoretic methods, there is minimal involvement of ions other than the drug, further reducing tissue disruption. We have designed effective gold electrode assemblies and observed the depletion and release phenomena using electrochemical methods and charged dyes.