|About this Abstract
||2018 TMS Annual Meeting & Exhibition
||Bio-nano Interfaces and Engineering Applications Symposium
||Single Molecular Imaging of Fluorescent-tagged Peptides Diffusing on a Surface of Boron Nitride
||Peiying Li, Takakazu Seki, Linhao Sun, Yuhei Hayamizu
|On-Site Speaker (Planned)
Specific peptides can spontaneously organize on a solid surface. Functionalization of surfaces of inorganic materials with these peptides is essential for biological applications, such as biosensor, drag delivery. Recently, engineered peptides on two-dimensional materials have demonstrated a spontaneous organization into long-range ordered nanostructures with six-fold symmetry. During the process of self-organization, there are three steps: (1) binding, (2) diffusion, and (3) ordering.1 It is important to investigate these processes individually for the control of the self-organization. While the ordering of peptides has been studied, the diffusion process is not fully understood, due to technical difficulties in the atomic force microscopy. In the kinetics of peptide self-organization, the diffusion process is needed to be studied more systematically. We utilized a high-sensitive fluorescent microscopy with fluorescent tagged peptides for a single molecular imaging to quantitatively investigate the diffusion process. In the presentation, we will discuss quantitative physical parameters in the diffusion process.
||Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)