|About this Abstract
||2016 TMS Annual Meeting & Exhibition
||Biological Materials Science Symposium
||Chemotherapeutic-Induced Surface Degradation of Subcutaneous Venous Access Ports - A Preliminary Comparative In-Vitro and In-Vivo Study
||Maren Kirknes Fossum, Charlotta Tegnestedt, Kristina Dahlberg, Emma Strömberg, Javier Sanchez, Håkan Wallén, Annelie Liljegren, Claes Frostell, Gunilla Björling, Ragnhild E. Aune
|On-Site Speaker (Planned)
||Maren Kirknes Fossum
Subcutaneous Venous Access Ports (SVAPs) are commonly used for administration of chemotherapeutic drugs in treatment of patients with cancer. A comparative in-vitro and in-vivo study has been performed to investigate the degradative effect that the chemotherapeutic drugs and whole blood have on the inner- respectively outer material surfaces of polyurethane SVAPs.
The duration of the in-vitro part was 18 weeks (6 treatments), and all experiments were conducted in a simulation-chamber allowing the control of medical drug flow rate, temperature, humidity, UV-exposure and atmospheric pressure. The surface structure and topography of the collected material samples were analyzed after each treatment using standard characterization techniques. In the in-vivo part, SVAP clinically exposed in accordance to the same medical protocol were collected after 6 treatments and analyzed using the same characterization methods. The obtained comparative results prove that in-vitro studies can be used to predict in-vivo outcomes when performed under well-controlled conditions.
||Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)