|About this Abstract
||Materials Science & Technology 2011
||MS&T'11 Poster Session
||022 Sintering and Bioactivities of Hydroxyapatite
||Monica Sawicki, Kyle Crosby, Ling Li, Leon Shaw, Yong Wang
|On-Site Speaker (Planned)
Hydroxyapatite (HA) is the main inorganic mineral of bone. The use of HA in orthopedic implants supports bone ingrowth and osseointegration due to its bioactivity. The typical sintering temperature for dense HA bodies is 1100°C or higher. In this study, sintering of HA at temperatures lower than 1100°C is enabled by HA nano-rods synthesized from a wet precipitation process. To investigate the effect of grain sizes on the bioactivity, various sintering temperatures have been employed to create HA bodies with grain sizes ranging from ~100 nm to tens of micrometers. The relationships between the sintering temperature, grain size, and final density are established. The bioactivities of the HA bodies in terms of cell attachment and proliferation are investigated with the aid of ROS17/2.8 cells and MTT assay, while cell morphologies are studied using scanning electron microscopy. The mechanism of the effect of grain sizes on the bioactivity will be discussed.