Additive manufacturing (AM) of metals could revolutionize the design and production of complex, high-value metal parts. However, the extreme processing conditions create deleterious microstructures with high stresses, extreme compositional gradients, non-equilibrium phases, and a variety of build flaws. How can the processing and post-processing treatments be optimized to produce useable and consistent microstructures and mechanical properties? We are developing a methodology to answer three questions: what is there?, how did it get there?, and how can we fix what is there? The route to qualification of AM materials requires close control of the build process (including design of experiment predictions and processing feedback loops), state-of-the-art characterization of the as-built microstructure and stresses, multicomponent computational thermodynamic and kinetic microstructural evolution simulations, and additional characterization at every step of the post-build processing. We will describe our progress in our first target systems, Inconel 625 and 17-4 steel.