| About this Abstract |
| Meeting |
2017 TMS Annual Meeting & Exhibition
|
| Symposium
|
High Entropy Alloys V
|
| Presentation Title |
Pre-osteoblastic Cell Responses to High-entropy Alloys |
| Author(s) |
Jinbo Dou, Haoyan Diao, Yunzhu Shi, Peter K. Liaw, Shanfeng Wang |
| On-Site Speaker (Planned) |
Shanfeng Wang |
| Abstract Scope |
High-entropy alloys (HEAs) have advantages as potential bone-tissue-engineering materials. Here the AlxCoCrFeNi (x = 0.3, 0.5, and 0.7) HEAs were used as substrates to examine the effects of composition, surface roughness, grain size, and surface phase on the in vitro mouse pre-osteoblastic MC3T3-E1 cell attachment and proliferation, in comparison with Ti as the positive control. Al0.3CoCrFeNi was prepared by hot-isostatic processing, while the other two HEAs and Ti were prepared in the as-cast condition. The rough surfaces were polished to 600-grit surface finish, while the smooth surfaces were 1,200-grit surface finish. Different Al compositions in AlxCoCrFeNi HEAs resulted in different pre-osteoblastic cellular responses. Al0.5CoCrFeNi better supported MC3T3-E1 cell attachment and proliferation, showing the promise as a potential biomaterial for orthopaedic applications. Rough surfaces had scratches that could align MC3T3-E1 cells while smooth ones did not. The different grain sizes resulted from the processing methods also affected the MC3T3-E1 cellular behavior. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |