|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||High Entropy Alloys V
||Pre-osteoblastic Cell Responses to High-entropy Alloys
||Jinbo Dou, Haoyan Diao, Yunzhu Shi, Peter K. Liaw, Shanfeng Wang
|On-Site Speaker (Planned)
High-entropy alloys (HEAs) have advantages as potential bone-tissue-engineering materials. Here the AlxCoCrFeNi (x = 0.3, 0.5, and 0.7) HEAs were used as substrates to examine the effects of composition, surface roughness, grain size, and surface phase on the in vitro mouse pre-osteoblastic MC3T3-E1 cell attachment and proliferation, in comparison with Ti as the positive control. Al0.3CoCrFeNi was prepared by hot-isostatic processing, while the other two HEAs and Ti were prepared in the as-cast condition. The rough surfaces were polished to 600-grit surface finish, while the smooth surfaces were 1,200-grit surface finish. Different Al compositions in AlxCoCrFeNi HEAs resulted in different pre-osteoblastic cellular responses. Al0.5CoCrFeNi better supported MC3T3-E1 cell attachment and proliferation, showing the promise as a potential biomaterial for orthopaedic applications. Rough surfaces had scratches that could align MC3T3-E1 cells while smooth ones did not. The different grain sizes resulted from the processing methods also affected the MC3T3-E1 cellular behavior.
||Planned: Supplemental Proceedings volume