|About this Abstract
||Materials Science & Technology 2011
||MS&T'11 Poster Session
||005 Calcium Phosphates for Drug Carrier: Adsorption and Release Kinetics of Drugs and Growth Factors
||Solaiman Tarafder, Amit Bandyopadhyay, Susmita Bose
|On-Site Speaker (Planned)
Lovastatin (LOV) is a cholesterol lowering drug. 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibition by lovastatin stops inhibition of osteoblast activity, and promoting osteoclast activity. Glutamic acid (GA), an amino acid, in addition to being a neuro-transmitter can also regulate bone cell activities by glutamate signaling. Objective of this research is to understand the chemistry of adsorption and release kinetics of LOV and GA in β-tricalcium phosphate (β-TCP) based ceramics. The sigmoidal adsorption isotherm of LOV shows a cooperative effect, indicating interaction between neighboring adsorbed molecules. DSC thermogram shows an endothermic peak at 184 °C due to adsorbed lovastatin on TCP. No release detection of lovastatin or low release of GA could be due to complex formation of with Ca2+. GA is a metal chelating agent which makes it capable for strong chemical interactions with metallic ions. Interaction and release behavior of growth factors with calcium phosphates have also been investigated.