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Meeting 2017 TMS Annual Meeting & Exhibition
Symposium Advanced Materials in Dental and Orthopedic Applications
Presentation Title Biomimetic Tooth Repair: Amelogenin-derived Peptides Enable In Vitro and In Vivo Enamel Remineralization
Author(s) Deniz Tanil Yucesoy, Carolyn Gresswell, Sanaz Saadat, Hanson Fong, Sami Dogan, Mehmet Sarikaya
On-Site Speaker (Planned) Deniz Tanil Yucesoy
Abstract Scope Demineralization of enamel is the earliest clinical sign of dental caries and if left untreated it can progress to clinical caries and other dental ailments. Incorporating a functional mineral layer that can be fully integrated into underlying molecular tooth structure in repairing damaged enamel has been a long-standing challenge. We described a protocol to remineralize enamel both in vitro in extracted human teeth and in vivo in a rat model using designed peptides in a variety of media, including water based solutions, gels and pastes. The amelogenin-derived peptides, ADPs, were designed using biocombinatorial selection via phage display, similarity analysis using bioinformatics, and an iterative binding and mineralization assays to control Ca-P minerals, their morphology and formation kinetics. The principles and procedures laid out here constitute the basis for translation into practical clinical application to address demineralization-related problems both as preventive dental health care as well as therapeutics.
Proceedings Inclusion? Planned: Supplemental Proceedings volume

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

A New Ni-free Beta-Ti Alloy with Large and Stable Room Temperature Super-elasticity
A Novel Strengthening Strategy Using Stacking Faults for Biomedical Co–Cr–Mo Alloys
Biodegradable Boron Coating for Wound Healing and Bone Regeneration Implants Via; DIMOX, Rheocasting and Thixocasting
Biomimetic Tooth Repair: Amelogenin-derived Peptides Enable In Vitro and In Vivo Enamel Remineralization
Cellular Response of Escherichia Coli to Mg-2Zn-2Gd Alloy with Different Grain Structure: Mechanism of Disruption of Colonization
Characterization of Chitin Synthesized from Snail Shell
Examining the Long-Term Exposure Effects of Simulated Body Fluid on the Behavior of Chitosan Bonded to Titanium Using Three Biocompatible Solvents
Failure Analysis and Fatigue Properties of a New Generation -based Ti-Nb Alloy and Cp-4 Titanium Osteosynthesis Plates
Functionalization of Dental Titanium Implants for Improved Osteointegration
H-1: Changing in the Elastic Modulus of Ti-10Mo-Zr System Alloys by Specific Heat Treatments
H-2: Correlation between the Presence of Martensitic Phase and Mechanical Properties of Ti-15Mo-xZr Alloys with Potential Orthopedic Application. Alloys with Potential Orthopedic Application
H-4: Structure and Microstructure of Ti-25Ta-Zr Alloys
H-5: Titanium-magnesium Composite for Dental Implants (BIACOM)
Microstructures and Properties of Mg AZ Alloys Subject to High Shear Deformation
Preparation and Characterizations of Nano Composites Based on Biphasic Mixture of Bioactive Ceramics for Biomedical Applications
Rapid Mechanical Assessment of Dental Materials for the Mitigation of Cracks in Natural Teeth
Repelling Biofilm Formation on Dental Materials via Piezoelectric Fillers
Surface Modified Drug Releasing Total Hip Implant
Tailoring of the Mechanical Properties of Alloys of the Ti-Zr-Mo System through Alloying and Heat Treatments
The Effects of Inclusions on the Fatigue Performance of Superelastic Nitinol Fine Wires
Thermomechanical Processing of Beta-Ti Alloys for Load-bearing Implant Applications

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