About this Abstract |
Meeting |
MS&T22: Materials Science & Technology
|
Symposium
|
Society for Biomaterials: Biomaterial Applications
|
Presentation Title |
Bioactive Polyelectrolyte Layer by Layer Assembled Corrosion Resistant Coatings on Surface Treated MgAZ31 Alloys |
Author(s) |
Prashant Nagesh Kumta, Sangeetha Kunjukunju, John Ohodnicki, Abhijit Roy, Boeun Lee, Joe Candiello |
On-Site Speaker (Planned) |
Sangeetha Kunjukunju |
Abstract Scope |
Polyelectrolyte layer by layer (LbL) coatings on pretreated MgAZ31 substrates were prepared under physiological conditions to improve bioactivity and corrosion resistance. Pretreatment of MgAZ31 was achieved using alkaline and fluoride media methods. LbL-film assembly comprised of an initial polyethyleneimine layer followed by poly (lactic-co-glycolic acid) and poly(allylamine hydrochloride), that self-assemble via electrostatic interactions on the pretreated MgAZ31 surface. The LbL-films were characterized by FTIR, XRD, SEM, and AFM to analyze their physicochemical characteristics, surface morphologies, and microstructures. Electrochemical impedance spectroscopy measurements indicate that pretreated and LbL-coated substrates improved corrosion resistance of bare MgAZ31. Cytocompatibility studies using hMSC cells seeded directly on the substrates showed that the pretreated and LbL coated substrates are more cytocompatible and less cytotoxic than bare MgAZ31. Lastly, sustained release of BSA from the LbL-coated substrates was demonstrated reflecting the potential of using LbL coatings on magnesium-based scaffolds to enhance their surface bioactivity. |