|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Bio-Nano Interfaces and Engineering Applications
||Early Study on Surface Nano-engineering of Endovascular Zinc Implants and Resulting Effects on Biodegradation and Biocompatiblity
||Adam Drelich, Roger J. Guillory, Jeremy Goldman, Jaroslaw Drelich
|On-Site Speaker (Planned)
Recent in vivo study with zinc (Zn) revealed that this material biodegrades at varying rates over time, with slower degradation occurring in the first few weeks due to a surface oxide film. This intriguing, yet unexplained phenomenon prompted us to introduce a revolutionary concept in engineering biodegradable stents: stents with a graded degradation rate. In this study, both thickness and structure of an oxide film on Zn are manipulated through oxidation, electropolishing and anodization. Zinc wires of different surface finish were implanted into the abdominal aorta lumens of rats for up to 8 weeks, per our vascular implant model, to assess the degradation rate and corrosion uniformity, identify corrosion products, assess biocompatibility of blood borne and vascular cells, quantify smooth muscle cell intimal hyperplasia, and assess toxicity. Our results reveal striking differences in in vivo corrosion rates and provide fundamental insights into how zinc corrosion regulates inflammation and neointimal hyperplasia.
||Planned: Supplemental Proceedings volume