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Meeting 2016 TMS Annual Meeting & Exhibition
Symposium Advanced Materials in Dental and Orthopedic Applications
Presentation Title Titanium Oxide Nano-bio Interactions: Repercussions in Health Effects
Author(s) Ana Ribeiro, Sara Gemini-Piperni, Wanderson Souza, Renata Travassos, Leandro Lemgruber, Renata Carvalho, André Rossi, Tolou Shokhufar, Luis Rocha, Jacques Werckmann, José Granjeiro
On-Site Speaker (Planned) Ana Ribeiro
Abstract Scope The current understanding of nano-bio interactions is still in its infancy but it is important to foster such knowledge since it has implications in nanosafety. In this study we explore the nano bio interactions of titanium oxide nanoparticles (Ti NPs) by microscopy techniques and by proteomics and correlate the obtained results with bone cells toxicity. Cytotoxicity studies reveals no toxicity despite a high Ti NPs internalization by cells. Results demonstrate the presence of a biological complex surrounding Ti NPs rich in proteins but also calcium and phosphorus ions. More interesting was the precipitation of hydroxyapatite crystals on these complexes. Since calcium and phosphorous are the main ions involved in bone mineralization our hypothesis is that this bio-complexes formed acts as a “trojan horse” during the process of NPS internalization. These findings provide new information of the nano-bio interface, an essential knowledge to understand the safer use of Ti nanoparticles.
Proceedings Inclusion? Planned: A print-only volume


Beta-type Titanium Alloys for Use as Rods in Spinal Fixation Devices
Bioactivity and Mechanical Stability of Ti6Al4V Implant Superplastically Embedded with Hydroxyapatite (HA) in Rats
C-1: DMP1 Peptides Surface Modification of Titanium Implants
C-2: Evaluation of Dental Archwires Following Flex Bending Fatigue
C-3: Surface Chemistry Examination and Adhesion Testing of Chitosan Bonded to Titanium Using Biologically Compatible Solvents
C-4: Understanding Dental Pulp Stem Cells Response to Spider Silk
Dental and Orthopaedic Implants with Surface TiO2 Nanotubes for Enhanced Osseo-Integration
Development of Novel Beta Ti-Mo-Zr Alloys for Orthopedic Applications
Diagnostics and Dental Materials for Crack Mitigation in Natural Teeth
Effect of MMT Nanoparticle Clay on Flexural Properties of Polymer Based BisGMA/TEGDMA Resin
Examining the Effects of Three Biologically Compatible Solvents on the Behavior of Chitosan Bonded to Titanium
Improving the Compatibility of a Veneering Ceramic System Using a New Graded Interlayer Composition
In-Vivo Performance and Characterization of Nanostructured Orthopedic Surfaces
Interfacial Properties of Cellulose Nanocrystals for Biomedical Applications
Mechanically Strong TiO2 Nanotubes for Hip Implants
Miniature Medical Implants from Nanostructured Titanium
Novel Approach for Manufacturing Technological Based Characterization of Residual Strength Behavior of Ceramic for Dental Applications
One-step Anodic Deposition of HA with Ag Nanoparticles on Titanium for Anti-bacterial and Bioactive Implant
Overview of Degradation Phenomena in Dentistry and Orthopedics
Polymeric Coating for Optimization of Drug Release from Drug-Loaded Surfaces
Processing, Microstructure Characterization and Biological Response of Cold Sprayed Biocomposite Coatings
Room Temperature Aging of Ti-Nb based Beta Alloys
Structural Characteristics and Mechanical Behavior of Selective Laser Sintered Porous Ti-6Mo Alloy for Biomedical Applications
Surface Amorphization of NiTi Alloy Induced by Ultrasonic Nanocrystal Surface Modification for Biomedical Applications
Surface Treatments and Dental Implant Infections
Tensile Mean Strain Effects on the Fatigue Behavior of Superelastic Nitinol
The Growing Orthopedic Infection Problem: Can Anything Stop It ?
The Improvement in Fatigue, Biocompatibility and Corrosion Resistance of Low Modulus Beta Titanium Alloy using UNSM & LSP
Thermal Stability and Structural Characteristics of Metastable Beta-type Ti-Nb Alloys for Implant Applications
Titania Nanotube Arrays as Interfaces for Neural Prostheses
Titanium Oxide Nano-bio Interactions: Repercussions in Health Effects
Vanadium Interactions in Biological Systems

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