|About this Abstract
||2016 TMS Annual Meeting & Exhibition
||Advanced Materials in Dental and Orthopedic Applications
||Titanium Oxide Nano-bio Interactions: Repercussions in Health Effects
||Ana Ribeiro, Sara Gemini-Piperni, Wanderson Souza, Renata Travassos, Leandro Lemgruber, Renata Carvalho, André Rossi, Tolou Shokhufar, Luis Rocha, Jacques Werckmann, José Granjeiro
|On-Site Speaker (Planned)
The current understanding of nano-bio interactions is still in its infancy but it is important to foster such knowledge since it has implications in nanosafety. In this study we explore the nano bio interactions of titanium oxide nanoparticles (Ti NPs) by microscopy techniques and by proteomics and correlate the obtained results with bone cells toxicity.
Cytotoxicity studies reveals no toxicity despite a high Ti NPs internalization by cells. Results demonstrate the presence of a biological complex surrounding Ti NPs rich in proteins but also calcium and phosphorus ions. More interesting was the precipitation of hydroxyapatite crystals on these complexes. Since calcium and phosphorous are the main ions involved in bone mineralization our hypothesis is that this bio-complexes formed acts as a “trojan horse” during the process of NPS internalization.
These findings provide new information of the nano-bio interface, an essential knowledge to understand the safer use of Ti nanoparticles.
||Planned: A print-only volume