Gas separation technology between propane/propylene is very important in the petrochemical industry. Here, several intriguing questions arise in the practice of the gas separation: 1) what is the best porous material for propane/propylene separation? and 2) what's the most significant property for improving the gas separation? To answer these questions, we perform high-throughput screening (HTS) approach from the Cambridge Structural Database (CSD) and Inorganic Crystal Structural Database (ICSD) along with a grand canonical Monte-Carlo simulation, and the total number of all crystal structures is approximately 1,000,000. As indicators of gas separation performance, selectivity and working capacity can be considered. In this work, we clarify correlations between physical properties of porous materials (e.g. heat of adsorption, surface area, and pore volume) and selectivity/working capacity from the HTS approach. To our best knowledge, this work is the first study to apply to the HTS approach in a field of gas separation.