|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Bio-Nano Interfaces and Engineering Applications
||Engineering Hydrogels with Bioactive Nanomaterials for Bone Regeneration Applications
||Settimio Pacelli, Ryan Maloney, Arghya Paul
|On-Site Speaker (Planned)
Non-union fractures and critical sized bone defects have great difficulty healing without intervention. Tissue engineering strategies aim to recreate bone’s natural healing processes on a fabricated scaffold with cells and therapeutics for implantation. One class of materials used for both therapeutics and in vitro modeling are hydrogels. However, the fragile mechanical properties of hydrogels limit their application in heavy load-bearing regions of bone. Inclusion of nanomaterials within the polymeric hydrogel network can both increase the strength of the network and allow exploitation of their unique abilities to interact with encapsulated cells and therapeutics. Here, we report that the inclusion of nanodiamonds, octahedral carbon-based biocompatible nanoparticles, can both improve the mechanical properties of gelatin-based hydrogels, enable dexamethasone loading and delivery to encapsulated human adipose-derived mesenchymal stem cells. In addition, we demonstrate multiple other biomedical applications of gelatin/nanodiamond based hydrogels, such as in delivery of biotherapeutics, microscale patterning and bioprinting.
||Planned: Supplemental Proceedings volume