|About this Abstract
||Materials Science & Technology 2012
||Surface Properties of Biomaterials III
||Surface Modification of Graphene Oxide and Its Biocompatibility
||S Seal, S Das, L Zhai, S Khondekar, W Self, J Dowding
|On-Site Speaker (Planned)
The association of cellular response with the physiochemical properties of graphene-based materials is largely unexplored.In this presentation, we report an in-vitro biological assessment of RGO and GO in correlation with their physiochemical properties. GO surface is found to be more reactive to cells than equivalently sized RGO. GO and RGO induced significant increases in both intercellular reactive oxygen species (ROS) levels and mRNA levels of heme oxygenase 1 (HO1) and thioredoxin reductase (TrxR). Moreover, significant amount of DNA damage was observed in GO treated cells, but not in RGO treated cells. Interestingly, oxidative stress induced cytotoxicity exposed to RGO reduced with decreasing extent of oxygen functional group density on the RGO surface. Therefore, it can be concluded that although size of the GO sheet plays a role, the functional surface group density on the GO sheet is thought to be one of the key component in mediating cellular cytotoxicity.
||Planned: None Selected