|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Biological Materials Science
||Peptide-Enabled Materials & Systems for Technology & Medicine
||Mehmet Sarikaya, David Starkebaum, Carolyn Gresswell, Deniz T Yucesoy, Hanson Fong
|On-Site Speaker (Planned)
Genetically Engineered Peptides for Inorganic solids (GEPI) are of a broad interest due to their capability for functionalization of solids and as molecular linkers, erector sets and assemblers as well as enzymes to synthesize solids in molecular technologies and nanomedicine. Refining combinatorial mutagenesis approaches (cell surface and phage display libraries) originally adapted from the principles of drug design, our laboratory has been experimentally selecting 100s of solid-binding peptides for a variety of metals, oxides, semiconductors, minerals, and 2D single layer materials. To acclerate directed evolution process, bioinformatics methods have been established for de novo designing multifunctional peptides in chimeric, modular constructs. Latest developments will be discussed in designing GEPIs with specific surface recognition and assembly characteristics augmented by computational modeling (MD and kMC) and present examples in quantum dot assembly on LED displays, graphene FET cancer biosensors, biofunctionalization of implants, and cell-free tissue reconstruction. Supported by NSF-DMREF and LSDF.
||Planned: Supplemental Proceedings volume