This study investigates the prestraining effect on failure during hole-expansion (HE) test of AA6022-T4 aluminum alloy sheet, for which the material is subjected to uniaxial prestraining followed by the HE test. The given test condition inevitably involves non-proportional loading path and prior deformation effect, in the spirit of multi-step forming operations used in industry. The full-field strain is measured by the Digital Image Correlation (DIC) system in every test. For prestraining, a wide specimen is stretched up to 8% of uniaxial deformation, which is equivalent to half of the max. uniform elongation. An HE specimen is then manufactured from the prestrained specimen, and the HE test is performed on a double-action hydraulic press with a punch dia. of 100 mm. In the experiments, the clear variation of thickness around the circumference is observed. This distribution is dependent on the prestraining direction, and is compared to the non-prestrained (i.e., as-received) HE test. Finite element (FE) simulations of the experiments are also conducted. The material model consists of the Yld2000-2d anisotropic yield function for the initial yield surface and Homogeneous Anisotropic Hardening (HAH) model, which is based on distortional hardening, to take into account the strain path change. The material parameters of the Yld2000-2d model are calibrated by uniaxial tension, plane-strain tension, and disk compression tests, and the ones of the HAH model are found by tension-compression and two-step tension tests with loading path changes. The simulation results for punch force-displacement and thickness strain variation around the circumference are compared with experiments.