Samples produced using laser deposition of metallic powders often exhibit distributions of porosity, coarse columnar microstructures, and possess significant residual stresses. This presentation describes research aimed at eliminating (or at least significantly reducing) porosity, and modifying microstructure, for example, producing equiaxed microstructures using variations in alloy composition. In this way, alloys are being produced that respond to the processing technique, rather than using conventional compositions which, in the processed condition, contain defects and unattractive microstructures. The factors that influence the choice of alloying elements to be used in these new alloys include those elements that result in a change in solidification mode, those that have been used as inoculants in cast alloys, and those that will reduce the surface tension of liquid titanium alloys. The results of these experiments will be described, which will include not only materials characterization but also mechanical property determination.