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Meeting Materials Science & Technology 2010
Symposium Next Generation Biomaterials
Presentation Title Magnetic Vascular Implants Promote Rapid Endothelialization
Author(s) Brant Newman, Dan Dragomir-Daescu, Adrianna Harbuzariu, Malcolm McIntosh, Jonathan Harburn, Anthony Parakka, Manju Kalra, David Holmes, Robert Simari, Gurpreet Sandhu
On-Site Speaker (Planned) Brant Newman
Abstract Scope Atherosclerosis is the most prevalent and costly public health threat in the world (WHO, 2006). Treatment often involves surgical placement of a vascular graft or stent, but these interventions are susceptible to thrombosis, inflammation, and neointimal hyperplasia in vivo. We designed and tested novel, rapidly-endothelializing, magnetic vascular grafts and stents. First, endothelial outgrowth cells endocytosed superparamagnetic microspheres in culture. The cells were then seeded onto magnetic stents and grafts for in vivo experimentation. Fourteen stents were implanted into pigs, showing superior resistance to inflammation, thrombosis, and neointimal hyperplasia relative to bare metal stents. Similarly, endothelial cell coated cobalt chromium – poly(ether urethane) composite grafts were implanted into pig arteries, exhibiting improved patency at one month follow-up. These studies facilitated materials selection and design of cardiovascular implants with superior efficacy and reduced development time.
Proceedings Inclusion? Planned: At-meeting proceedings

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

Alteration of Dentin-Enamel Mechanical Properties Due to Common Dental Whitening Treatments and Preparation for Restorative Procedures
Apatite Nano-Rods Array Grown on Glass Substrates in Aqueous Systems
Assembly of Carbon Nanotube-collagen Macroscopic Structures by a Novel Electrochemical Process
Assessing the Effect of Surface Roughness on Corrosion Resistance of Ternary Nitinol Alloys
Biomaterials:New Insights by ab Initio Calculations and Advanced Solid State NMR
Boron Nitride Nanotube: A Novel Reinforcement for Hydroxyapatite
Cell Adhesion to Borate Glasses: An Atomic Force Microscopy Study
Colossal Supersaturation with Interstitial Solutes: Perspectives for Surface Engineering of Medical Devices
Comparison of Microstructures and Mechanical Properties for Solid and Mesh Cobalt-Base Alloy Components and Biomedical Implant Prototypes Fabricated by Electron Beam Melting
Composites and Scaffolds for Calcified Tissue Regeneration
Controlled Drug Delivery from Medical Devices with Biodegradable Polymer Composites: a Multi-Scale Modeling Approach
Dental Application Field Based on Nanostructural Chemically Bonded Ca-aluminate.
Development of a Uniaxial Chewing Simulator
Development of Electrosprayed PLA/CDHA Coatings on Biomedical Implants
Dielectric Properties of Porous Calcium Titanate (CaTiO3)
Effect of TiB2 or Y2O3 Additions on Mechanical Biofunctionality of Ti-29Nb-13Ta-4.6Zr for Biomedical Applications Biomedical Applications
Enhanced Functions of Osteoblasts on Biomimetic Nanohydroxyapatite-Grafted Chitosan Scaffolds for Bone Tissue Engineering
First-Principles and CALPHAD Approaches to Identification of Biodegradable Magnesium Alloys
Formation of Hydroxyapatite from Solid Precursor Material in the Presence of Phosphonates
Fracture and Fatigue Behavior of Wires Used in the Biomedical Industry
Freeze-form Extrusion Fabrication of 13-93 Bioactive Glass Scaffolds for the Repair and Regeneration of Load-Bearing Bones
Functionalized Magnetic Nanoparticles for Targeted Drug and Gene Delivery
Gum Arabic-chitosan-hydroxyapatiteComposite Biopolymer Scaffolds for Bone Tissue Engineering
In Vitro and In Vivo Corrosion Evaluation of Organo-Silane-Coated Magnesium-Yttrium Alloy
In Vitro Validation of Two-Dimensional Patient-Specific Finite Element Analysis of Proximal Femoral Strength
Iron/Iron Oxide Core/Shell Nanoparticles for Magnetic
Magnetic Vascular Implants Promote Rapid Endothelialization
Mechanical Characterization of Biomineralized HAP-Collagen Composites
Nanostructured Al2TiO5-based Composite: Bioactivity, Structure and Mechanical Property Studies
Nanostructured Biomaterials: Potential, Challenges and Needs
Novel Beta Titanium Alloys and Surface Engineering Approaches for Orthopedic Implants
Novel Low Temperature Synthesis of Stabilized Alpha-Tricalcium Phophate
Novel Nanoclay Based Bone Tissue Engineered Scaffolds: Experiments and Modeling
Optimization of Elastic Modulus-Density Relationships for Finite Element Models of the Proximal Femur
Organic-inorganic Nanocomposites for Biomedical Applications
Patient-Specific Finite Element Models of Proximal Femur Stiffness and Fracture Load During a Sideways Fall on the Hip
Porous Biodegradable Scaffolds for Hard Tissue Engineering
Porous Metal Oxide by Self-Assembling Agarose Templation
Predicting Microstructure Evolution in Drug Eluting Coatings
Preparation of Porous Hydroxyapatite Scaffolds Using Yeast as a Pore Forming Agent
Processing of Improved Scaffolds for Bone Generation (Invited)
Reactive Electrospinning Approach for Nanoporous PLA/ Monetite Nanocomposite Fibers
Selective Laser Sintering Fabrication of Bioglass Bone Scaffolds
Stable Nanocolloids of Low Soluble Drugs Using Sonication Assisted Layer-by-Layer Technique
Synthesis of Nano Hydroxyapatite by Chemical Precipitation Using Different Surfactant Templates
Synthesis, Characterization and Bioactivity of Silicate Matrix Bioceramics
The Effect of Sulfur on Conversion of Bioactive Borate Glass to Hydroxyapatite
Towards A Better Structural Characterization of Substituted Hydroxyapatites
Transparent Nanocrystalline Hydroxyapatite by Pressure-Assisted Sintering
Ultrafine-grained Commercially Pure Titanium and Microstructure Response to Hydroxyapatite Coating Methods

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