In this presentation, we will present the friction and wear behavior of a single-phase body-centered cubic equiatomic TiZrHfNb high-entropy alloy using nanoscratch method. The friction behavior appears to be divided into two distinct regimes, namely, elastic and plastic dominated deformations, based on the scratched morphologies, surface profiles, and friction coefficient evolution. In the elastic regime, the friction coefficient decreases rapidly with increasing normal load and can be well predicted by the Hertz model. By contrast, friction coefficient is essentially independent of normal load and follows Amontons’ law in the plastic regime. The wear can be expressed by well-known Archard dry wear equation. Scratch rate appears to have a negligible effect on the friction and wear behavior. Compared to the pure Nb and a commercial bcc-Nb-based C103 alloy, current high-entropy alloy shows a lower friction coefficient and greater wear resistance. This result indicates high-entropy alloys have good potential for tribological applications.