A full hydrometallurgy of retrieving copper, indium and zinc from lead matte is represented in this paper. Leaching solution which contains copper, indium and zinc is obtained by pressure leaching, various factors such as discussed sulfuric acid concentration, temperature, pressure, liquid-solid ratio, leaching time, grinding time are discussed. The leaching rate of copper, indium and zinc are 95%,88% and 97% under the optimum conditions respectively. Separating copper and indium by extraction under the situation of high-acid, concentration of extractant, mixing time, mixing ratio, extraction stage and multi-stage counter current extraction are investigated. The recovery rate of copper and indium are 94% and 98% if multi-stage counter current extraction under the optimum conditions is carried out.