Biodegradable polymers are widely used for the development of numerous engineering products due to their superior multifunctional properties such as, low density, biodegradability, biocompatibility, and fairly good mechanical properties. In recent years, these materials are being used for making of a wide variety of sophisticated medical devices such as, orthopaedic fixation devices, ligature clips, tissue staples, and stents. In the present research endeavour, the drilling behaviour of biodegradable polymer namely; polylactic acid (PLA) has been experimentally investigated. The drilling of PLA was performed at different levels of feed (8, 16, and 24 mm/min.) and speed (700, 1400 and 2100 RPM) using different drill bits namely; twist drill bit, multifaceted drill bit, and dagger drill bit. The influence of the input parameters on the drilling induced force and damage has been experimentally investigated. The temperature distribution during the drilling of biodegradable polymer has also been investigated to emphasize the drilling mechanism.