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Meeting 2016 TMS Annual Meeting & Exhibition
Symposium Bio Nano Interfaces and Engineering Applications
Presentation Title Stimuli Responsive and Reconfigurable Nanoparticle Biointerfaces
Author(s) Marc R Knecht
On-Site Speaker (Planned) Marc R Knecht
Abstract Scope Through the weak and non-covalent interactions of peptides with inorganic nanomaterials, selective and responsive biointerfaces are possible that are prohibited by the strong covalent binding of standard ligands that locks the molecules into a single configuration. Unfortunately, biomolecules are not typically responsive to external stimuli to trigger molecular reconfiguration, thus modification of the structure is required. By merging a peptide with known affinity for Au with a non-biological photoactuatable molecule, azobenzene, stimuli-responsive nanoparticle biointerfaces have been realized. The hybrid biomolecule maintains substantial affinity for Au; however, its biomolecular configuration on a nanoparticle can been reversibly reconfigured via azobenzene isomerization based upon photo-illumination without destabilizing the nanoparticle. Interestingly, the photoisomerization rate, and thus biomolecular reconfiguration, is highly dependent upon the inorganic composition. These results pave the way toward controllable and reconfigurable nanoparticle biomolecular interfaces to engender a single nanosystem with multiple functionalities/properties that are independently and selectively enabled.
Proceedings Inclusion? Planned: Publication Outside of TMS (Indicate publication title and publisher if known.)

OTHER PAPERS PLANNED FOR THIS SYMPOSIUM

An Electrochemical Approach to Control Surface Behavior of Peptides Self-assembling on Graphite
Analytical Study on the Effect of Interface Properties in Brick and Mortar Structured Composites
Bacterial Surface Display for Discovery and Study of Peptide-Directed Material Interfaces
Biological Fabrication of Nanodevices by Protein Supramolecules
Coarse-Grained Modeling of Interaction between Vesicle and Active Rotational Nanotube
Computational Models of Peptide-Surface Interactions Drawn from Bacterial Display Studies: Up Close and Personal
Computational Strategies for Amyoloidogenic Proteins Interacting with Gold NPs
D-1: Elucidation of Sequence-Dependent Structure/Function Relationships for Bimetallic CoPt Nanoparticles
D-2: High Affinity Surface Attachment of F1 Rotary Motors for Nanodevice Fabrication
D-3: Selection of Peptide Aptamer with Ultrahigh Affinity for TiO2 by Combination of Phage Display and Electroporation
D-4: Self-healing in Super-tough Double Network Hydrogels
Design Rules for Molecularly Interfacing Biology and Engineered Solids towards Biomimetic Devices
Designer Self-assembling Peptides for Programming the Bio-material Interface
Effect of Water on the Mechanical Properties of Lignin Carbohydrate Complex
Engineered Interfaces for Dehydrogenase Based Self-Integrated Electrode System
Engineering of Bio-Nano Interfaces on 2D Nanomaterials by Self-Assembled Peptides
Engineering of Biodegradable Boron-Based, Carbon Enriched Nano Fiber in A Hybrid Composite Via DIMOX, Rheocasting and Thixocasting
Gene Expression Profiling of Preosteoblasts on Conventional and Nanostructured Bulk Titanium
Graphene Oxide Reinforced Double Network Hydrogel
Graphite Oxide/Cellulose Composites as Innovative Solid Support Material for DNA Extraction Applications
How Do Nano and Microscale Surface Topographies Affect Bacterial Attachment? Designing a New Generation of Antimicrobial Surfaces
Implantable Magnetic Nanocompsites for Cancer Treatment
Interrogating Bio-Nano Interactions and Enhancing Materials Properties
Mechanism of Specific Recognition of Pt Nanocrystals by Peptides and of their Formation from Seed Crystals
Modeling the Organic-Inorganic Nano Interface in Nanocomposites in Bone Tissue Engineering
Molecular-level Understanding of Peptide Adsorption at Fluid/Solid Interfaces through Molecular Simulation and Its Exploitation in Practise
Nonuniform Breaking of Molecular Bonds, Peripheral Morphology, and Releasable Adhesion by Elastic Anisotropy in Bio-adhesive Contacts
Novel Gyratory Methods for Forming Smart Biointerfaces
Precision Assembly of Biologically Functional Abiotic/Biotic Materials
Recluse Spider's Silk Nanoribbons — a Quasi-2D Protein Material with Outstanding Mechanical and Adhesive Properties
Rules of Induction Towards Chimeric Antimicrobial Peptide Design as Implant Biocoatings
Self-reinforced Fibro-porous 3D Tubes for Vascular Graft Applications
Stimuli Responsive and Reconfigurable Nanoparticle Biointerfaces
Synthesis of Self-cleaning, Transparent and Superhydrophobic/Oleophobic Metal Oxide Coatings by Atmospheric Pressure Plasma Technique
The Structure and Mechanics of the Interfaces within Biological and Bio-inspired Materials
Thermodynamic Characterization of Self-Assembled Peptides on Graphite

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