|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Recent Developments in Biological, Structural and Functional Thin Films and Coatings
||Osteogenic Potential of a Biomimetic Layer-by-layer Platform
||Khalil Abdelkebir, Fabien Gaudière, Laura Tesson, Jean-Pierre Vannier, Hassan Atmani, Sandrine Morin-Grognet, Béatrice Labat, Guy Ladam
|On-Site Speaker (Planned)
Implant osseointegration remains a continuing challenge in bone surgery. Biomimetic Layer-by-Layer (LbL) coatings comprising chondroitin sulfate A, a biological polyanionic glycosaminoglycan of bone tissue, and poly-L-lysine, a polycationic polypeptide, are promising, versatile candidates for inducing biomineralization directly at implant surfaces. In a first, physico-chemical approach, films enriched with phosphoproteins displayed unique, promoting influence on the heterogeneous nucleation of calcium phosphate, leading to thin uniform layers of biologically-relevant mineral phases. In a second, biological approach, cytophilicity of the LbL coatings was improved by treatments with genipin, a biological crosslinking agent with less cytotoxicity than current chemical crosslinkers. Structural changes within the LbL films were elucidated, in particular by means of a newly discovered FRET couple involving genipin. The osteogenic potential of genipin-treated LbL films was clearly enhanced in vitro. A complementary approach based on osteogenic drugs embedded into the LbL films used as nanoreservoirs is ongoing.
||Planned: Supplemental Proceedings volume