“High-Entropy Materials (HEMs)” has become a new emerging field through the collective efforts of many researchers since 1995. High mixing entropy can enhance the formation of solution-type phases for alloys, ceramics and composites, and in general leads to simpler microstructure. Large degrees of freedom in composition design as well as process design could provide a wide range of microstructure and properties for applications. There are many opportunities for HEMs to overcome the bottlenecks of conventional materials. In this presentation, several breakthrough applications are pointed out and emphasized. They include aerospace turbines and nozzles, car turbochargers, molds and dies, cutting tools, hard facings, radiation-damage resistant materials, cryogenic piping and containers, and low TCR thin-film resistors.