|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Recent Developments in Biological, Structural and Functional Thin Films and Coatings
||H-39: Structure Property Relationship of Tannic Acid Based Copolymers for Anti-oxidant Infused Wound Dressing
||Matthew Korey, John A. Howarter
|On-Site Speaker (Planned)
In early 1900’s, tannic acid was the main method used to treat acute, third-degree burn wounds. However, after the discovery that tannic acid (TA) was leeching into the bloodstream of patients and causing severe liver damage, its use in this therapy was discontinued. More recent studies have shown the effectiveness and selectivity through which the end groups of tannic acid can be chemically modified with acid anhydrides. In order to localize the tannic acid to the burn wound and to not allow it to leech into the blood stream, it was proposed that a tannic acid macromer would be generated by chemical modification of the end groups of tannic acid with methacrylic anhydride and then radically co-polymerized with hydroxyethyl methacrylate (HEMA), a bio-friendly polymer. The mechanical properties, pH stability, degradation and leeching of this copolymer into solution were studied and correlated with molecular structure and composition.
||Planned: Supplemental Proceedings volume